Hailey and Hailey Disease

I need help creating a thesis and an outline on Hailey and Hailey Disease. Prepare this assignment according to the guidelines found in the APA Style Guide. An abstract is required. The lesions are symmetrical, itchy and burning. Sometimes some foul-smelling discharge can be present which can contribute to the misery of the patient. The disease is difficult to diagnose and challenging to treat. Many treatment modalities are available and there are no clear guidelines as to who has to be treated with what medication. Complications can occur, which are however not life-threatening. It is very important to understand the pathophysiology of the disease process to establish a diagnosis and provide appropriate treatment. In this research article, the causes, pathophysiology and few treatment aspects of the disease will be discussed through a review of appropriate literature.

Hailey and Hailey disease, also known as Familial benign pemphigus, is an inherited skin disorder (Helm, 2012). It is a chronic autosomal disorder with incomplete penetrance. It was first described by Hailey brothers in 1939 and hence the name (Helm, 2012). According to Rooks Text Book of Dermatology, “Familial benign chronic pemphigus or Hailey–Hailey disease (Mendelian Inheritance in Man (MIM) accession number 169600) is a rare intraepidermal, blistering disease that is inherited as an autosomal dominant with a prevalence of around 1 in 50 000.” (Burns et al, 2010). Patients with this condition present with lesions of the skin. The lesions are mainly erythematous plaques and vesicles with overlying crusts. Areas that are mainly involved are genital regions, axillary regions, under the breasts, neck and chest (Helm, 2012). The lesions have a burning sensation and are itchy. There can be a malodorous discharge when secondary bacterial infection occurs. The disease mainly involves the skin and not the mucosa. Nails also can get involved, but they are asymptomatic. Nails can have white longitudinal bands. Pits can also occur in the palms. Longitudinal leukonychia may help in establishing the diagnosis (Rao, 2013).&nbsp.

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