The most common drugs to control brain and kidney tumors are mTOR inhibitors such as sirolimus and everolimus. Screening tests such as magnetic resonance imaging (MRI), an ultrasound scan, spirometry, echocardiogram and blood tests can help to identify tumors connected with tuberous sclerosis. Appropriate diagnostic and treatment plans are quite necessary for successful health care and support of patients with tuberous sclerosis. Tuberous sclerosis the other name tuberous sclerosis complex(TSC) is a genetic disease. It is characterized by the formation of benign, noncancerous tumors in the different organs of human body such as kidney, lungs, brain, heart, eyes and skin. Benign tumors formed in the human body when function of cell growth is damaged. Abnormal quantity of cells formed an extra mass surrounded by outer layer and cause different negative health defects. The statistics show that the most common benign tumors caused by tuberous sclerosis occur in the brain and in skin in 9 causes between 10. kidney and eyes 8 cases between 10. in kidney 8 cases out of 10 and more rarely in the lungs 4 cases between10 especially in women. Tumors in the brain can cause different neurological defects and abnormal brain function. The most common disorder of the nervous system during tuberous sclerosis is epilepsy. It is a long-term neurological defect that characterized by repeated spasms, convulsions and loss of consciousness. Tumors in the brain can cause different neurological defects.